ARUP's Laboratory Test Directory

ALK Gene Rearrangements in NSCLC for Crizotinib Eligibility by FISH : 2006102

Mnemonic: ALK GENE

Methodology: Fluorescence in situ Hybridization
Performed: Varies
Reported: 7-10 days
Specimen Required: Collect: Tumor tissue.

Specimen Preparation: Formalin fix (10 percent neutral buffered formalin) and paraffin embed tumor tissue. Transport tissue block or 4 unstained, consecutively cut, 5-micron thick sections, mounted on positively charged glass slides. (Min: 4 slides) Protect paraffin block and/or slides from excessive heat.

Storage/Transport Temperature: Room temperature. Also acceptable: Refrigerated.

Remarks: Include surgical pathology report with reason for referral. The laboratory will not reject specimens that arrive without a pathology report but will hold the specimen until this information is received.

Stability (collection to initiation of testing): Ambient: Indefinitely; Refrigerated: Indefinitely; Frozen: Unacceptable
Reference Interval:
By report
CPT Code(s): 88271 x2 DNA probe each, 88274 Interphase in situ hybridization 25-99 each; 88291 Interpretation and report
Cross References: Lung Cancer, ALK (2p23) Rearrangement, FISH, Tissue, Lung carcinoma, Non-small cell lung cancer, Non-small Cell Lung Cancer (NSCLC) Therapeutic Panel: EGFR Mutation Analysis and ALK FISH Analysis (ALK Gene Rearrangements in NSCLC for Crizotinib Eligibility by FISH) , NSCLC, Soft-FLCA
 
 

 

 

 
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