Reference Interval:
By report
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| Interpretive Data: |
Background Information for HLA Bone Marrow Transplantation Evaluation:
Purpose: To screen recipients and potential donors for allogenic hematopoietic stem cell transplantation.
Methodology: PCR followed by Sequence Specific Oligonucleotide Probe Hybridization of HLA-A,B and DRB1 alloantigens.
Analytical Sensitivity & Specificity: Low to medium resolution for HLA-A and B loci and medium to high resolution for HLA-DRB1 loci.
Limitations: Additional testing is necessary to identify genotypic or allele level match. If less than 2 alleles are reported for a locus, the patient is likely homozygous. Rare diagnostic errors can occur due to primer or probe site mutations
Counseling and informed consent are recommended for genetic testing. Consent forms are available online at www.aruplab.com.
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| Note: |
The relationship of each donor to the recipient must be denoted on each donor's test request form. If at all possible, submit specimens from all family members (including parents of the recipient) at the same time. Interpretation and evaluation of potential donors can only be performed if relationships for family members are established by the client.
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| CPT Code(s): |
83891 Isolation; 83898 Amplification; 83900 Multiplex Amplification; 83896 x10 Nucleic acid probes; 88384 Probes 11-50; 88385 Probes 51-250; 83912 Interpretation and report -Additional CPT code modifiers may be required for procedures performed to test for oncologic or inherited disorders.
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Cross References: |
High Resolution Class I Typing (HLA Bone Marrow Transplantation Evaluation) |
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