ARUP's Laboratory Test Directory

Celiac Disease Dual Antigen Screen with Reflex : 2002026

Mnemonic: CELIAC SCRN

Methodology: Semi-Quantitative Enzyme-Linked Immunosorbent Assay
Performed: Mon, Wed, Fri
Reported: 1-6 days
Specimen Required: Collect: Serum separator tube.

Specimen Preparation: Separate serum from cells ASAP or within 2 hours of collection. Transfer 2 mL serum to an ARUP Standard Transport Tube. (Min: 1 mL)

Storage/Transport Temperature: Refrigerated.

Unacceptable Conditions: Plasma. Contaminated, hemolyzed, or grossly lipemic specimens.

Stability (collection to initiation of testing): After separation from cells: Ambient: 8 hours; Refrigerated: 8 days; Frozen: 1 year (if frozen within 24 hours)
Reference Interval:
 
 
Test Number Components Reference Interval
0051689Celiac Disease Dual Antigen Screen 19 Units or less: Negative - No significant level of detectable IgA or IgG antibodies against human tissue transglutaminase or gliadin peptide.

20 Units or greater: Positive - Presence of IgA and/or IgG antibodies against human tissue transglutaminase and/or gliadin peptide; suggests possibility of certain gluten sensitive enteropathies such as celiac disease and dermatitis herpetiformis.
0097709Tissue Transglutaminase (tTG) Antibody, IgA 19 Units or less: Negative
20-30 Units: Weak Positive
31 Units or greater: Moderate to Strong Positive
0056009Tissue Transglutaminase Antibody, IgG < 20 EU: None Detected
20-30 EU: Weakly Positive
> 30 EU: Positive
0051357Deamidated Gliadin Peptide (DGP) Antibody, IgA 19 Units or less: Negative
20-30 Units: Weak Positive
31 Units or greater: Positive
0051359Deamidated Gliadin Peptide (DGP) Antibody, IgG 19 Units or less: Negative
20-30 Units: Weak Positive
31 Units or greater: Positive

Interpretive Data: Refer to individual components.
Note: The Celiac Disease Dual Antigen Screen is a combined antibody assay for tissue transglutaminase and deamidated gliadin-derived peptide antibodies, IgA and IgG.

If Celiac Disease Dual Antigen Screen is 20 Units or greater, then tTG IgA and Gliadin Peptide IgA will be added. If tTG IgA and Gliadin Peptide IgA are negative, tTG IgG and Gliadin Peptide IgG will be added. Additional charges apply.
CPT Code(s): 83516 Dual antigen screen. If Dual antigen screen is 20 Units or greater, add 83516 tTG IgA and 83516 Gliadin IgA. If tTG IgA and Gliadin IgA are negative, add 83516 tTG IgG and 83516 Gliadin IgG.
Cross References: Gluten Sensitivity Screen (Celiac Disease Dual Antigen Screen with Reflex)
 
 

 

 

 
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