Reference Interval:
Reports include age appropriate reference intervals and interpretation.
| Components
| Reference Interval
| | α-β+ & CD4- & CD8-%
| By report
| | α-β+ & CD4- & CD8-#
| By report
| | CD5+ & CD20+%
| By report
| | CD5+ & CD20+#
| By report
| | CD3+ & HLA-DR+%
| By report
| | CD3+ & HLA-DR+#
| By report
|
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| Interpretive Data: |
In Autoimmune Lymphoproliferative Syndrome (ALPS), all three of the lymphocyte subsets (alpha-beta positive, CD4 negative, and CD8 negative; CD5 positive and CD20 positive; and CD3 positive and HLA-DR positive) are elevated above the reference intervals. CD5 and HLA-DR may be found normally on B-cells and T-cells, respectively, as activation markers. Autoantibody production from CD5 positive B-cells is likely responsible for the autoimmune phenomena seen in ALPS. Increased levels of TCR alpha-beta positive, CD4 negative, and CD8 negative T-cells are the hallmark of ALPS and play a significant role in the pathophysiology of the disease.
Refer to Statement A under Testing Information at http://www.aruplab.com.
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| CPT Code(s): |
86356 CD3; 86356 CD4; 86356 CD5; 86356 CD8; 86356 CD20; 86356 ALPHA/BETA; 86356 HLA-DR
|
Cross References: |
Alpha-Beta+, Double Negative (CD4-, CD8-) (Autoimmune Lymphoproliferative Profile), ALPS (Autoimmune Lymphoproliferative Profile), Canale-Smith Syndrome (Autoimmune Lymphoproliferative Profile), T-Cells for Autoimmune Lymphoproliferative Syndrome (ALPS) (Autoimmune Lymphoproliferative Profile) |