CBFB-MYH1, inv(16) by RT-PCR : ARUP Lab Tests

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CBFB-MYH1, inv(16) by RT-PCR : 0092209

Time Sensitive

Mnemonic: INV(16)

Methodology:	Reverse Transcription Polymerase Chain Reaction
Performed:	Varies
Reported:	4-7 days
Specimen Required:	Collect: Lavender (EDTA) or bone marrow (EDTA). Specimen Preparation: Transport 5 mL whole blood or 3 mL bone marrow. (Min: 1 mL whole blood or 1 mL bone marrow) Specimens must be received within 48 hours of collection due to lability of RNA. Storage/Transport Temperature: Refrigerated. Unacceptable Conditions: Serum or plasma. Specimens collected in preservatives other than EDTA. Frozen specimens. Clotted or severely hemolyzed specimens. Stability (collection to initiation of testing): Ambient: 1 hour; Refrigerated: 48 hours; Frozen: Unacceptable

Interpretive Data:	Refer to report. Refer to Statement B under Testing Information at http://www.aruplab.com.
Note:	CBFB (core binding factor β-chain)-MYH11 (myosin heavy chain 11 gene) fusion transcripts are detected in approximately 10% of de novo acute myelogenous leukemias (AML). One half of these cases belong to AML subtype M4 with abnormal eosinophils (AML-M4Eo). The fusion results from a pericentric inversion on chromosome 16 inv(16)(p13q22) or rarely from the translocation t(16;16)(p13;q22). Based on the breakpoints in the CBFB and MYH11 genes, greater than 95% of analyzed inv(16) cases belong to three types: A (88%), D (5%), and E (5%).
CPT Code(s):	83891 Isolation; 83902 Reverse transcription; 83898 x5 Amplification; 83894 x3 Gel separation; 83912 Interpretation and report - Additional CPT code modifiers may be required for procedures performed to test for oncologic or inherited disorders.
Cross References:	inv(16) (CBFB-MYH1, inv(16) by RT-PCR)

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