ARUP's Laboratory Test Directory

Tricyclic Antidepressant Identification Quantitative, Serum : 0090154

Mnemonic: TADID

Methodology: Quantitative Liquid Chromatography-Tandem Mass Spectrometry
Performed: Sun-Sat
Reported: 1-3 days
Specimen Required: Collect: Plain red. Also acceptable: Lavender (K2 or K3EDTA) or pink (K2EDTA).

Specimen Preparation: Separate serum or plasma from cells within 2 hours of collection. Transfer 1 mL serum or plasma to an ARUP Standard Transport Tube. (Min: 0.5 mL)

Storage/Transport Temperature: Refrigerated.

Unacceptable Conditions: Whole blood. Gel separator tubes, light blue (citrate), or yellow (SPS or ACD solution).

Stability (collection to initiation of testing): After separation from cells: Ambient: 5 days; Refrigerated: 2 weeks; Frozen: 6 months
Reference Interval:
Therapeutic Range:
 
Drug Sensitivity Therapeutic Range Toxic
Amitriptyline (Elavil, Vanatrip) Less than 10 ng/mL   
Nortriptyline Less than 10 ng/mL   
Total Amitriptyline + Nortriptyline  95-250 ng/mL Greater than 500 ng/mL
Imipramine (Tofranil) Less than 10 ng/mL   
Desipramine Less than 10 ng/mL   
Total Imipramine + Desipramine  150-300 ng/mL Greater than 500 ng/mL
Doxepin (Sinequan, Zonalon) Less than 10 ng/mL   
Nordoxepin Less than 10 ng/mL   
Total Doxepin + Nordoxepin  100-300 ng/mL Greater than 400 ng/mL
Protriptyline (Vivactil) Less than 10 ng/mL 70-240 ng/mL Greater than 400 ng/mL
Clomipramine (Anafranil) Less than 25 ng/mL   
Norclomipramine Less than 25 ng/mL   
Total Clomipramine/Metabolite  220-500 ng/mL Greater than 900 ng/mL
Nortriptyline only  (Aventyl, Pamelor) Less than 10 ng/mL 50-150 ng/mL Greater than 500 ng/mL
Desipramine only (Norpramin) Less than 10 ng/mL 100-300 ng/mL Greater than 500 ng/mL

Note: This test is used for screening, identifying, and quantitating the following tricyclic antidepressants: amitriptyline, clomipramine, desipramine, doxepin, imipramine, norclomipramine, nordoxepin, nortriptyline, and protriptyline.
CPT Code(s): 80100 if negative; if positive use the appropriate CPT code(s) for drug identified as follows: 80152 Amitripyline; 80182 Nortriptyline; 80174 Imipramine; 80160 Desipramine; 80166 Doxepin; 80299 Nordoxepin; 80299 Protriptyline; 80299 Clomipramine; 80299 Norclomipramine.
Cross References: Amitriptyline (Tricyclic Antidepressant Identification Quantitative, Serum), Clomipramine (Tricyclic Antidepressant Identification Quantitative, Serum), Doxepin (Tricyclic Antidepressant Identification Quantitative, Serum), Imipramine and Desipramine (Tricyclic Antidepressant Identification Quantitative, Serum), Norclomipramine (Tricyclic Antidepressant Identification Quantitative, Serum), Nordoxepin (Tricyclic Antidepressant Identification Quantitative, Serum), Nortriptyline (Tricyclic Antidepressant Identification Quantitative, Serum), Protriptyline (Tricyclic Antidepressant Identification Quantitative, Serum), TADID (Tricyclic Antidepressant Identification Quantitative, Serum), TCA Screen (Tricyclic Antidepressant Identification Quantitative, Serum), Tricyclic Antidepressant Unknown (Tricyclic Antidepressant Identification Quantitative, Serum)
 
 

 

 

 
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