| Interpretive Data: |
Cyclosporine A levels in specimens drawn 2 hours post-dose may estimate the AUC better than trough specimens. The therapeutic range for C2 specimens depends on factors such as cyclosporine formulation, co-administered medications, transplant organ, patient health, and time post-transplant. A suggested target range for renal transplant is 800-1700 ng/mL, and 600-1000 ng/mL for liver transplant, with high levels immediately post-transplant, and low levels in the maintenance phase.
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| Note: |
Cyclosporine (Sandimmune®) whole blood concentrations can be measured by either chromatographic or immunoassay methodologies. These two methodologies are not directly interchangeable, and the measured cyclosporine whole blood concentration depends on the type of assay used. Reference ranges may vary according to the specific immunoassay or LC/MS/MS test used. Generally, immunoassays have been reported to have a positive bias relative to the reference assay, HPLC with detection by tandem mass spectrometry (LC/MS/MS).
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| CPT Code(s): |
80158
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Cross References: |
Gengraf (Cyclosporine A , C2 by Tandem Mass Spectrometry), Neoral® (Cyclosporine A, C2 by Tandem Mass Spectrometry)
, Restasis (Cyclosporine A, C2 by Tandem Mass Spectrometry), Sandimmune® (Cyclosporine A, C2 by Tandem Mass Spectrometry)
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