ARUP's Laboratory Test Directory

Paraneoplastic Syndrome Antibody Panel with Reflex to ANNA Titer, PCCA Titer and Neuronal Immunoblot : 0051226

Mnemonic: NEOPLASTIC

Methodology: Semi-Quantitative Indirect Fluorescent Antibody/Qualitative Immunoblot
Performed: Wed
Reported: 1-9 days
Specimen Required: Collect: Serum separator tube.

Specimen Preparation: Separate serum from cells ASAP or within 2 hours of collection. Transfer 2 mL serum to an ARUP Standard Transport Tube. (Min: 0.75 mL)

Storage/Transport Temperature: Frozen.

Unacceptable Conditions: Contaminated, heat-inactivated, hemolyzed, or lipemic specimens.

Stability (collection to initiation of testing): After separation from cells: Ambient: 24 hours; Refrigerated: 2 weeks; Frozen: 1 year

Reference Interval:
 
Test Number Components Reference Interval
 Neuronal Nuclear Antibody (ANNA) IgG Screen, by IFA < 1:10
0050892Neuronal Nuclear Antibody (ANNA) Reflex IFA Titer, IgG < 1:10 No antibody detected
0059444Purkinje Cell Cytoplasmic Antibody by IFA with Reflex to Titer & Immunoblot  
 
Components Reference Interval
Purkinje Cell Cytoplasmic Ab (PCCA or PCA-1) Screen Less than 1:10
Purkinje Cell Cytoplasmic Ab (PCCA or PCA-1) Titer < 1:10
Purkinje Cell Cytoplasmic Ab (PCCA or PCA-1) Immunoblot Negative
 Purkinje Cell Antibody, Titer < 1:10
 Neuronal Nuclear Antibody IgG, Immunoblot Anti-Hu Negative
 Neuronal Nuclear Antibody IgG, Immunoblot Anti-Ri Negative
0051091Neuronal Antibody IgG, Immunoblot Anti-Yo Negative

Note: ANNA antibodies are screened by IFA. If the IFA screen is positive at 1:10, then a titer and immunoblot (Hu and Ri) will be added. If Purkinje cell screen is positive at 1:10, then a titer and immunoblot (Yo) will be added. Additional charges apply.
CPT Code(s): 86255 ANNA; if reflexed, add 86256 ANNA titer and 83516 Immunoblot; 86255 Purkinje cell screen; if reflexed, add 86256 Purkinje titer
Cross References: ANNA and PCCA IFA (Paraneoplastic Syndrome Antibody Panel with Reflex to ANNA Titer, PCCA Titer and Neuronal Immunoblot)
 
 

 

 

 
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