Reference Interval:
Monozygotic twins: Greater than 99% certainty (all markers match).
Dizygotic twins: 99% certainty (two or more markers do not match).
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| Interpretive Data: |
Background Information:
Characteristics: Monozygotic twins originate from a single fertilized ovum dividing into two embryos, while dizygotic twins result from ovulation of two eggs during a single menstrual cycle.
Incidence: Twins are delivered 1 in 77 Caucasian births; 70% are dizygotic and 30% are monozygotic.
Inheritance: Multifactorial
Cause: Dizygotic twinning is related to increased levels of maternal follicle stimulating hormone.
Clinical Sensitivity: 99%
Methodology: PCR followed by capillary electrophoresis; specimens are analyzed using 15 autosomal short tandem repeat markers (D8S11 79, D21S11, D7S820, CSF1PO, D3S1358, THO1, D13S317, D16S539, D2S1338, D19S433, vWa, TPOX, D18S51, D5S818 and FGA) and one gender marker (Amelogenin).
Analytic Sensitivity: 99%
Limitations: Specificity may be compromised by rare primer site mutations.
Refer to Statement B under Testing Information at http://www.aruplab.com.
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| Note: |
Results from both twins will be compared; therefore a specimen from each twin must be obtained and genotyped.
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| CPT Code(s): |
83891 Isolation; 83909 Separation and identification; 83900 Amplification; 83901 x14 Multiplex amplification; 83912 Interpretation and report
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Cross References: |
Fetal Zygosity (Twin Zygosity Testing), Mono/Dizygotic Differentiation (Twin Zygosity Testing), Newborn Zygosity (Twin Zygosity Testing), Zygosity, Twin Pre/Postnatal (Twin Zygosity Testing) |
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