Metanephrines, Plasma (Free) : ARUP Lab Tests

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Metanephrines, Plasma (Free) : 0050184

Mnemonic: META PF

Methodology:	Quantitative Liquid Chromatography-Tandem Mass Spectrometry
Performed:	Sun-Sat
Reported:	2-6 days
Specimen Required:	Patient Prep: Epinephrine and epinephrine-like drugs may affect results, and should be discontinued for at least 72 hours prior to specimen collection, if possible. Collect the specimen after the patient has rested for 15 minutes in a supine position. Collect: Lavender (EDTA), pink (K₂EDTA), or green (sodium or lithium heparin). Collect specimen and place in ice bath. Specimen Preparation: Centrifuge within 1 hour. Transfer 2 mL plasma to an ARUP Standard Transport Tube and freeze immediately. (Min: 1 mL) Avoid hemolysis. Storage/Transport Temperature: CRITICAL FROZEN. Separate specimens must be submitted when multiple tests are ordered. Remarks: Unacceptable Conditions: Plasma separator tubes. Body fluids other than EDTA or heparinized plasma. Non-frozen or icteric specimens. Stability (collection to initiation of testing): After separation from cells: Ambient: Unacceptable; Refrigerated: Unacceptable; Frozen: 1 month

Reference Interval: Normetanephrine: 0.0-0.89 nmol/L Metanephrine: 0.0-0.49 nmol/L
Interpretive Data:	Patients with essential hypertension and plasma concentrations of normetanephrine and metanephrine below 0.9 nmol/L and 0.5 nmol/L, respectively, can be reliably excluded from further testing for the detection of a pheochromocytoma. The majority of patients with pheochromocytoma have a plasma normetanephrine concentration in excess of 2.2 nmol/L and/or metanephrine concentration in excess of 1.1 nmol/L. The presence of increased concentrations of the analytes serves as confirmation for the diagnosis of the tumor.
CPT Code(s):	83835
Cross References:	Metanephrine (Metanephrines, Plasma (Free)), Metanephrines, Fractionated (Metanephrines, Plasma (Free)), Normetanephrine (Metanephrines, Plasma (Free)), Quantitative Metanephrines (Metanephrines, Plasma (Free))

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